This page contains links to raw 16S rRNA gene sequence data from our CDC-funded studies on using fecal minibioreactors and humanized microbiota mice to study the impact of interpersonal microbiome variation on disruption following antibiotic treatment and its potential impact on susceptibility to Clostridioides difficile infection.
CDC Year 1 contains links to:
- 16S rRNA gene sequence data for human fecal minibioreactors colonized with feces from a healthy adult, antibiotic-treated adult, healthy toddler (<3 years old), or a healthy elder (>65 years old) that were either untreated or treated with cefaclor, clindamycin or fidaxomicin.
- Whole genome shotgun (WGS) sequence data for human fecal minibioreactors colonized with feces from a healthy adult that was either untreated or treated with cefaclor, clindamycin or fidaxomicin.
- 16S rRNA gene sequence data for humanized microbiota Swiss-Webster mice colonized with feces from a healthy or antibiotic-treated adult that were either untreated or treated with cefaclor, clindamycin or fidaxomicin.
- WGS sequence data for humanized microbiota Swiss-Webster mice colonized with feces from a healthy adult that were either untreated or treated with cefaclor, clindamycin or fidaxomicin.
CDC Year 2 contains or will contain (collection still in progress) links to:
- 16S rRNA gene sequence data for human fecal minibioreactors colonized with feces from healthy adults (n=7), healthy children (3-17 years old, n=3) or healthy elders (>65 years old, n=2) that were either untreated or treated with augmentin, azithromycin, cefaclor, ceftriaxone, ciprofloxacin, clindamycin, doxycycline, fidaxomicin, imipenem, metronidazole, sulfamethoxazole, or vancomycin.
- WGS sequence data for human fecal minibioreactors colonized with feces from a healthy adult, healthy child or healthy elder that was either untreated or treated with azithromycin, cefaclor, ceftriaxone, clindamycin, or fidaxomicin.
- 16S rRNA gene sequence data from humanized microbiota Swiss-Webster, C57Bl6/J, or C3H/HeN mice colonized with feces from a healthy adult, healthy child or healthy elder that was either untreated or treated with azithromycin, cefaclor, ceftriaxone, clindamycin, or fidaxomicin.
- WGS sequence data rom humanized microbiota C57Bl6/J mice colonized with feces from a healthy adult, healthy child or healthy elder that was either untreated or treated with azithromycin, cefaclor, ceftriaxone, clindamycin, or fidaxomicin.